发表论文
  

  1. Zhou C, Chen X, Planells-Cases R, Chu J, Wang L, Cao L, Li Z, López-Cayuqueo KI, Xie Y, Ye S, Wang X, Ullrich F, Ma S, Fang Y, Zhang X, Qian Z, Liang X, Cai SQ, Jiang Z, Zhou D, Leng Q, Xiao TS, Lan K, Yang J, Li H, Peng C, Qiu Z*, Jentsch TJ*, Xiao H*. Transfer of cGAMP into Bystander Cells via LRRC8 Volume-Regulated Anion Channels Augments STING-Mediated Interferon Responses and Anti-viral Immunity. Immunity. 2020 May 19; 52: 767-781. *Corresponding author. 

 

2. Xie Y, Zhao Y, Shi L, Li W, Chen K, Li M, Chen X, Zhang H, Li T, Yu MI, Yao X, Shao D, Ke Z, Li J, Chen Y, Zhang X, Cui J, Cui S, Leng Q, Cadwell K, Li X, Wei H, Zhang H, Li H, Xiao H*. Gut epithelial TSC1/mTOR controls RIPK3-dependent necroptosis in intestinal inflammation and cancer. J Clin Invest. 2020 Apr 1;130(4):2111-2128. *Corresponding author. 

 

3. Shi L, Chen X, Zang A, Li T, Hu Y, Ma S, Lü M, Yin H, Wang H, Zhang X, Zhang B, Leng Q*, Yang J*, Xiao H*. TSC1/mTOR-controlled metabolic-epigenetic cross talk underpins DC control of CD8+ T-cell homeostasis. PLoS Biol. 2019 Aug 21;17(8): e3000420. *Corresponding author.

 

 4. Wang W, Deng Z, Wu H, Zhao Q, Li T, Zhu W, Wang X, Tang L, Wang C, Cui SZ, Xiao H*, Chen J*. A small secreted protein triggers a TLR2/4-dependent inflammatory response during invasive Candida albicans infection. Nat Commun. 2019, Mar 4;10(1):1015. *Corresponding author. 

 

5. Liu L, Wan X, Zhou P, Zhou X, Zhang W, Hui X, Yuan X, Ding X, Zhu R, Meng G, Xiao H, Ma F, Huang H, Song X, Zhou B, Xiong S, Zhang Y. The chromatin remodeling subunit Baf200 promotes normal hematopoiesis and inhibits leukemogenesis. J Hematol Oncol. 2018 Feb 26;11(1):27.

 

 6. Zhou P, Ding X, Wan X, Liu L, Yuan X, Zhang W, Hui X, Meng G, Xiao H, Li B, Zhong J, Hou F, Deng L, Zhang Y. MLL5 suppresses antiviral innate immune response by facilitating STUB1-mediated RIG-I degradation. Nat Commun. 2018, Mar 28;9(1):1243.

 

 7. Zhang WC, Du LJ, Zheng XJ, Chen XQ, Shi C, Chen BY, Sun XN, Li C, Zhang YY, Liu Y, Xiao H, Leng Q, Jiang X, Zhang Z, Sun S, Duan SZ. Elevated sodium chloride drives type I interferon signaling in macrophages and increases antiviral resistance. J Biol Chem. 2018, Jan 19;293(3):1030-1039.

 

 8. Ma S, Wan X, Deng Z, Shi L, Hao C, Zhou Z, Zhou C, Fang Y, Liu J, Yang J, Chen X, Li T, Zang A, Yin S, Li B, Plumas J, Chaperot L, Zhang X, Xu G, Jiang L, Shen N, Xiong S, Gao X, Zhang Y, Xiao H*. Epigenetic regulator CXXC5 recruit DNA demethylase Tet2 to regulate TLR7/9-elicited IFN response in pDCs. J Exp Med. 2017, 214(5):1471-1491. *Corresponding author. 

 

 9. Wang J, He N, Zhang N, Quan D, Zhang S, Zhang C, Yu RT, Atkins AR, Zhu R, Yang C, Cui Y, Liddle C, Downes M, Xiao H, Zheng Y, Auwerx J, Evans RM, Leng Q. NCoR1 restrains thymic negative selection by repressing Bim expression to spare thymocytes undergoing positive selection. Nat Commun. 2017, 8(1):959. 

 

10. Javed N, Xue G, Lu A, Xing Y, Iwakura Y, Xiao H, Lecoeur H, Sp?th GF, Meng G. Cross reactivity of S. aureus to murine cytokine assays: A source of discrepancy. Cytokine. 2016, 81:101-108. 

 

11. Gong Q, Hu Z, Zhang F, Cui A, Chen X, Jiang H, Gao J, Chen X, Han Y, Liang Q, Ye D, Shi L, Chin YE, Wang Y, Xiao H, Guo F, Liu Y, Zang M, Xu A, Li Y. Fibroblast growth factor 21 improves hepatic insulin sensitivity by inhibiting mammalian target of rapamycin complex 1 in mice. Hepatology. 2016, 64(2):425-438. 


12. Zhu X, Shi D, Li X, Gong W, Wu F, Guo X, Xiao H, Liu L, Zhou H. TLR signaling affects sperm mitochondrial function and motility via phosphatidylinositol 3-kinase and glycogen synthase kinase-3α. Cell Signal. 2016, 28(3):148-156. 


13. Deng Z, Ma S, Zhou H, Zang A, Fang Y, Li T, Shi H, Liu M, Du M, Taylor PR, Zhu HH, Chen J, Meng G, Li F, Chen C, Zhang Y, Jia XM, Lin X, Zhang X, Pearlman E, Li X, Feng GS, Xiao H*. Tyrosine phosphatase SHP-2 mediates C-type lectin receptor-induced activation of the kinase Syk and anti-fungal TH17 responses. Nat Immunol. 2015, 16:642-652. *Corresponding author. 


14. Du M, Liu J, Chen X, Xie Y, Yuan C, Xiang Y, Sun B, Lan K, Chen M, James SJ, Zhang Y, Zhong J, Xiao H*. Casein Kinase II Controls TBK1/IRF3 Activation in IFN Response against Viral Infection. J Immunol. 2015, 194:4477-4488. *Corresponding author. 


15. He L, Zang A, Du M, Ma D, Yuan C, Zhou C, Mu J, Shi H, Li D, Huang H, Deng Q, Xiao J, Yan H, Hui L, Lan K, Xiong S, Li X, Huang Z, Xiao H*. mTOR regulates TLR-induced c-fos and Th1 responses to HBV and HCV vaccines. Virologica Sinica. 2015, 30:1-16. *Corresponding author. 


16. Yang C, Guo L, Liu J, Yang J, Zhu K, Xiao H*, Leng Q*. (2015) Non-Classical MHC I-E negatively regulates macrophage activation and Th17 cells in NOD mice. Sci Rep. 5:12941-12949. *Co-corresponding authors. 


17. James SJ, Jiao H, Teh HY, Takahashi H, Png CW, Phoon MC, Suzuki Y, Sawasaki T, Xiao H, Chow VT, Yamamoto N, Reynolds JM, Flavell RA, Dong C, Zhang Y. MAPK Phosphatase 5 Expression Induced by Influenza and Other RNA Virus Infection Negatively Regulates IRF3 Activation and Type I Interferon Response. Cell Rep. 2015, pii: S2211-1247(15)00176-X. 


18. Zhao Q, Liang D, Sun R, Jia B, Xia T, Xiao H, Lan K. (2015) Kaposi's sarcoma-associated herpesvirus-encoded replication and transcription activator impairs innate immunity via ubiquitin-mediated degradation of myeloid differentiation factor 88. J Virol. 89:415-427. 


19. Wang C, Wu L, Bulek K, Martin BN, Zepp JA, Kang Z, Liu C, Herjan T, Misra S, Carman JA, Gao J, Dongre A, Han S, Bunting KD, Ko JS, Xiao H, Kuchroo VK, Ouyang W, Li X. (2013) Thepsoriasis-associated D10N variant of the adaptor Act1 with impaired regulation by the molecular chaperone hsp90. Nat Immunol. 14:72-81. 


20. Gulen MF, Bulek K, Xiao H, Yu M, Gao J, Sun L, Beurel E, Kaidanovich-Beilin O, Fox PL, DiCorleto PE, Wang JA, Qin J, Wald DN, Woodgett JR, Jope RS, Carman J, Dongre A, Li X. (2012) Inactivation of the enzyme GSK3α by the kinase IKKi promotes AKT-mTOR signaling pathway that mediates interleukin-1-induced Th17 cell maintenance. Immunity, 37:800-812. 


21. Cui W, Xiao N, Xiao H, Zhou H, Yu M, Gu J, Li X. (2012) β-TrCP-mediated IRAK1 degradation releases TAK1-TRAF6 from the membrane to the cytosol for TAK1-dependent NF-κB activation. Mol Cell Biol. 32:3990-00. 


22. Kim TW, Yu M, Zhou H, Cui W, Wang J, DiCorleto P, Fox P, Xiao H, Li X. (2012) Pellino 2 is critical for Toll-like receptor/interleukin-1 receptor (TLR/IL-1R)-mediated post-transcriptional control. J Biol Chem. 287:25686-95. 

23. Chan ER, Hester J, Kalady M, Xiao H, Li X, Serre D. (2011) A novel method for determining microflora composition using dynamic phylogenetic analysis of 16S ribosomal RNA deep sequencing data. Genomics. 98:253-59. 


24. Yin W, Wan Y, Kim TW, Yao P, Xiao H, Zhou H, Xiao J, Fox P, Li X. (2011). The kinase activity of interleukin-1 receptor-associated kinase 2 is essential for lipopolysaccharide-mediated cytokine and chemokine mRNA stability and translation. J Interferon Cytokine Res. 31:415-22. 


25. Gulen MF, Kang Z, Bulek K, Youzhong W, Chen Y, Sass Bak-Jensen K, Do JS, Xiao H, Delgoffe GM, Powell JD, Tuohy VK, Cua DJ, Li X. (2010) The receptor SIGIRR suppresses Th17 cell proliferation via inhibition of the interleukin-1 receptor pathway and mTOR kinase activation. Immunity. 32:54-66. 


26. Xiao H#, Yin W, Khan M, Gulen MF, Zhou H, Sham HP, Jacobson K, Vallance BA and Li X. (2010) Loss of SIGIRR leads to enhanced colonic polyposis in Apcmin mice. Gastroenterology. 139:574-585. # First author 


27. Wan Y#, Xiao H#, Affolter J, Kim TW, Bulek K, Chaudhuri S, Carlson D, Hamilton T, Mazumder B, Stark GR, Thomas J, Li X. (2009) IRAK2 is critical for LPS-mediated post-transcriptional control. J Biol Chem. 284:10367-10375. # Co-first authors. 


28. Xiao H#, Qian W, Staschke K, Jiang Z, Qian Y, Cui G, Deng L, Chen ZJ, Gilmour R, Li X. (2008) Pellino 3b negatively regulates IL-1-induced TAK1-dependent NF?B activation. J Biol Chem. 283:14654-64. # First author  


29. von Bernuth H, Picard C, Jin Z, Pankla R, Xiao H, Ku CL, Chrabieh M, Mustapha IB, Ghandil P, Camcioglu Y, Vasconcelos J, Sirvent N, Guedes M, Vitor AB, Herrero-Mata MJ, Aróstegui JI, Rodrigo C, Alsina L, Ruiz-Ortiz E, Juan M, Fortuny C, Yagüe J, Antón J, Pascal M, Chang HH, Janniere L, Rose Y, Garty BZ, Chapel H, Issekutz A, Maródi L, Rodriguez-Gallego C, Banchereau J, Abel L, Li X, Chaussabel D, Puel A, Casanova JL. (2008) Pyogenic bacterial infections in humans with MyD88 deficiency. Science. 321:691-96. 


30. Fraczek J, Kim TW, Xiao H, Yao J, Wen Q, Li Y, Casanova JL, Pryjma J, Li X. (2008) The kinase activity of IRAK4 is required for TLR-IL-1R-induced TAK1-dependent NF?B activation. J Biol Chem. 283:31697-705.  


31. Xiao H#, Gulen MF, Qin J, Yao J, Bulek K, Kish D, Altuntas CZ, Walde D, Ma C, Zhou H, Tuohy VK, Fairchild R, de la Motte C, Cua D, Vallance BA, and Li X. (2007) The Toll-Interleukin-1 receptor member SIGIRR regulates colonic epithelia homeostasis, inflammation and tumorigenesis. Immunity. 26:461-75. # First author 


32. Kim TW, Staschke K, Bulek K, Yao J, Peters K, Oh KH, Vendenburg Y, Xiao H, Qian W, Hamilton T, Min B, Sen G, Gilmour R, Li X. (2007) A critical role for IRAK4 kinase activity in Toll-like receptor-mediated innate immunity. J Exp Med. 204:1025-36. 


33. Yao J, Kim TW, Qin J, Jiang Z, Qian Y, Xiao H, Lu Y, Qian W, Gulen MF, Sizemore N, DiDonato J, Sato S, Akira S, Su B, Li X. (2007) Interleukin-1 (IL-1)-induced TAK1-dependent Versus MEKK3-dependent NF?B activation pathways bifurcate at IRAK modification. J Biol Chem. 282:6075-89. 


34. Qin J, Yao J, Cui G, Xiao H, Kim TW, Fraczek J, Wightman P, Sato S, Akira S, Puel A, Casanova JL, Su B, Li X. (2006) TLR8-mediated NF?B and JNK activation are TAK1-independent and MEKK3-dependent. J Biol Chem. 281:21013-21. 


35. Xiao H#, Chung J, Kao HY, and Yang YC. (2003) Tip60 is a co-repressor for STAT3. J Biol Chem. 278:11197-204. # First author 


36. Xiao H#, Yin T, Wang X, Uchida T, Chung J, Morris WF, and Yang YC. (2002) Specificity of IL-2 receptor gamma chain superfamily cytokines is mediated by insulin receptor substrate-dependent pathway. J Biol Chem. 277:8091-98. # First author 


37. Xiao H#, Shen SC and Zhu JB. (1998) NifL, An antagonistic regulator of NifA, directly interacts with transcription activator NifA and NtrC. Science in China. 6:453-57. # First author 38. Xiao H#, Shen SC and Zhu JB. (1998) The Binding site and model of transcription activator SyrM to nodD3 promoter region. Science in China. 4:343-49. # First author