部分代表性论文：

　　Viral Infection and Immune Response

　　1.Kang, X., Xu, Y., Wu, X., Liang, Y., Wang, C., Guo, J. Wang, Y., Chen, M., Wu, D., Wang, Y., Bi, S., Qiu, Y., Lu, P., Cheng, J., Xiao, B., Hu, L., Gao, X., Liu, J., Wang, Y., Song, Y., Zhang, L., Suo, F., Chen, T., Huang, Z., Zhao, Y., Lu, H., Pan, C. and Tang, H. (2004) Proteomic Fingerprints for Potential Application to Early Diagnosis of Severe Acute Respiratory Syndrome.Clin. Chem. 51(1): 56-64.

　　**首次确立 SARS病毒感染的蛋白质谱指纹计算方法，成为SELDI-TOF诊断的金标准。

　　2.Perry AK, Chen G, Zheng DH, Tang H and Cheng G (2005) The host type I interferon response to viral and bacterial infections. Cell Res, 15(6):407-422.

　　3.Chen J, Chen L, Wang G and Tang H (2007) Cholesterol-dependent and independent CD40 internalization and signaling activation in cardiovascular endothelial cells. Arterioscler Thromb Vasc Biol, 27:2005-2013.

　　*脂筏内吞调节CD40-TRAF信号转导特异性，暗示他汀类药物调控炎性反应的新部位。

　　4. Kim K, Zhao J, Auh S, Yang X, Du P, Tang H*, and Fu Y* (2007) Adaptive immune cells temper initial innate responses. Nature Med 13(10):1248-1252 (*co-correspondence).

　　***提出炎性细胞TLR/RLR激活稳态维持需要初始化T细胞的新学说。

　　5. Zhao J, Kim KD, Yang X, Auh S, Fu YX* andTang H* (2008) Hyper innate responses in neonates lead to increased morbidity and mortality after infection.Proc Natl Acad Sci U S A 105(21):7528-33.(*co-correspondence)

　　***发现初始T细胞数目与炎性反应程度成反相关，进一步提出T细胞具有独立于T细胞受体之外的是天然免疫细胞功能，且对于免疫稳态维持至关重要。必读

　　6.Zheng D, Chen G, Guo B, Cheng G* and Tang H* (2008) PLP2, a potent deubiquitinase from murine hepatitis virus, strongly inhibits cellular type I interferon production. Cell Res, 18:1105–1113(*co-correspondence)

　　***首次发现冠状病毒Nsp3蛋白编码去泛素化酶，是该类病毒逃逸宿主细胞 I 型干扰素、建立急性感染的关键。必读

　　7.Zhao J, Yang X, Kim KD, Auh S, Fu YX* andTang H* (2009) Do adaptive immune cells suppress or activate innate immunity?Trends Immunol 30(1):8-12(*co-correspondence).

　　8. Mi Z, Fu J, Xiong Y and Tang H. (2010) SUMOylation of RIG-I positively regulates the type I interferon signaling. Protein Cell, 1(3):275-283.

　　***首次报道SUMO修饰是RLR激活的上游信号。必读

　　9.Fu J, Xiong Y, Xu Y, Cheng G andTang H. (2011) MDA5 is SUMOylated by PIAS2β in the upregulation of Type I interferon signaling.Mol Immunol. 48(4):415-22 (Epub 2010 Dec 14).

　　***首次报道PIAS2β是RLR SUMO化的E3连接酶。必读

　　10.Jiang J andTang H. (2010) Mechanism of inhibiting type I interferon induction by hepatitis B virus X protein.Protein Cell, 1(12):1106-17.

　　***首次发现乙肝病毒HBx蛋白编码去泛素化酶，是该病毒逃逸宿主细胞 I 型干扰素、建立慢性感染的关键。必读

　　11.Da Q, Yang X, Xu Y, Gao G, Cheng G, Tang H. (2011) TANK-Binding Kinase 1 Attenuates PTAP-Dependent Retroviral Budding through Targeting Endosomal Sorting Complex Required for Transport-I.J Immunol.186(5):3023-30 (Epub 2011 Jan 26).

　　12.Wang G, Chen G, Zheng D, Cheng G, Tang H (2011) PLP2 of Mouse Hepatitis Virus A59 (MHV-A59) Targets TBK1 to Negatively Regulate Cellular Type IInterferon Signaling Pathway. PLoS ONE 6(2): e17192. doi:10.1371/journal.pone.0017192.

　　13.Upadhyay V, Poroyko V, Kim T, Devkota S, Fu S, Liu D, Tumanov AV,Koroleva EP, Deng L, Nagler C, Chang EB, Tang H& Fu YX(2012) Lymphotoxin regulates commensal responses toenable diet-induced obesity. Nat Immunol, 13(10):947-53.

　　***首次发现TNFR家族LTβR控制肠道免疫器官生成，调节肠道感染炎性反应和肠道菌群结构，影响脂肪代谢。必读。

　　14.A Wu, C Su, D Wang, Y Peng, M Liu, S Hua, T Li, G Gao, H Tang, J Chen, X Liu, Y Shu, D Peng, T Jiang (2013). Sequential Reassortments Underlie Diverse Influenza H7N9 Genotypes in China. Cell Host & Microbe, 14:1-7.

　　15.X Wang, P Ying, F Diao, Q Wang, D Ye, C Jiang, N Shen, N Xu, W-B Chen, S Lai, S Jiang, X Miao, J Feng, W Tao, N Zhao, B Yao, Z Xu, H Sun, J Li, J Sha, X Huang, Q Shi, H Tang, X Gao and C Li (2013) Altered protein prenylation in Sertoli cells is associated with adult infertility resulting from childhood mumps infection. J Exp Med, 210(8):1559-74.

　　16.Chen J, Zhao Y, Zhang C, Chen H, Feng J, Chi X, Y Pan, J Du, M Guo, H Cao, H Chen, Z Wang, R Pei, Q Wang, L Pan, J Niu, X Chen and Tang H. (2014). Persistent hepatitis C virus infections and hepatopathological manifestations in immune-competent humanized mice. Cell Res, 24:1050–66. doi:10.1038/cr.2014.116.

　　***首次建立免疫系统完整、支持HCV持续感染并反映慢性丙肝病理进展的小鼠模型。必读。

　　17.Ma F, Feng J, Zhang C, Li Y, Qi G, Li H, Wu Y, Fu Y, Zhao Y, Chen H, Du J, &Tang H  (2014). The Requirement of CD8+ T Cells To Initiate and Augment Acute Cardiac Inflammatory Response to High Blood Pressure. J Immunol, 192(7), 3365-73.

　　**首次发现心肌应急性损伤由CD8+ T细胞启动，并通过募集和激活巨噬细胞侵润放大炎性信号。进一步拓展了T细胞具有天然免疫细胞样的功能。

　　淋巴细胞分化发育

　　18. Weng C, Li Y, Xu D, Shi Y, Tang H (2005) Specific cleavage of Mcl-1 by caspase-3 in TRAIL- induced apoptosis in Jurkat leukemia T cells. J Biol Chem, 280:(11) 10491–10500.

　　19. Qin, X. and Tang, H. (2006) Concerted regulation of chromatin structure of both the murine 3’ IgH enhancer and Igg2b promoter in response to LPS and CD40 signaling. Mol Immunol 43:1211–1220.

　　20. Pan L, Chen S,Weng C, Call G, Zhu D, Tang H, Zhang N and Xie T (2007) Stem Cell Aging Is Controlled Both Intrinsically and Extrinsically in the Drosophila Ovary.Cell Stem Cell, 1:458-469.

　　21. Li X, Yang X, Xu Y, Jiang X, Li X, Nan F, Tang H. (2009) Troglitazone inhibits cell proliferation by attenuation of epidermal growth factor receptor signaling independent of peroxisome proliferator-activated receptor gamma. Cell Res.19(6):669-71.

　　22. Yu J, Pan L, Qin X, Chen H, Xu Y, Chen Y, Tang H. (2010) MTMR4 Attenuates Transforming Growth Factor β(TGFβ)Signaling by Dephosphorylating R-Smads in Endosomes. J Biol Chem, 285(11):8454–8462.

　　23. Yu J, He X, Chen YG, Hao Y, Yang S, Wang L, Pan L, Tang H*. Myotubularin-related Protein 4 (MTMR4) Attenuates BMP/Dpp Signaling by Dephosphorylation of Smad Proteins. J Biol Chem. 288(1):79-88, 2013

　　24. Pan L, Wang S, Lu T, Weng C, Song X, Park K, Sun J, Yang ZH, Yu J, Tang H, McKearin DM, Chamovitz DA, Ni J, Xie T (2014). Protein competition switches the function of COP9 from self-renewal to differentiation. Nature, 514(7521):233-6.

　　专著：

　　1， B 细胞发育，《分子细胞生物学》，陈烨光，张传茂，陈全主编，第22章， pp414-426，清华大学出版社，北京，2006年（第一版），2011年（第二版）

　　2， 胸腺和T细胞发育，《分子细胞生物学》，陈烨光，张传茂，陈全主编，第23章， pp427-440，清华大学出版社，北京，2006年（第一版），2011年（第二版）

　　3， 炎症性细胞因子与疾病，《免疫学前沿进展》，曹雪涛主编，第19章，人民卫生出版社，北京，2009年（第一版），2011年（第二版），2016年（第三版）